STAT2 (UniProt/Swiss-Prot entry P52630) is a member of the STAT family of transcription factors. These transcription factors are activated by phosphorylation in response to cytokines and other growth factors. Once phosphorylated the proteins are translocated from the cytoplasm to the nucleus were they activate there target genes. As such STAT proteins act as both signal transducers and transcriptional activators. STAT2 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes and mediates antiproliferation and antiviral responses of the cell.
STAT2Y690p polyclonal antibody
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Alternative names: STAT113, P113, ISGF-3
Polyclonal antibody raised in rabbit against STAT2 (Signal Transducer And Activator Of Transcription 2) phosphorylated at Tyr690 using a KLH conjugated synthetic peptide.
| Lot | 001 |
|---|---|
| Concentration | 1.15 μg/μl |
| Species reactivity | Human, mouse, rat, dog, pig, horse, bovine, monkey |
| Type | Polyclonal |
| Purity | Affinity purified |
| Host | Rabbit |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Applications | Suggested dilution | References |
|---|---|---|
| Western Blotting | 1:1,000 | Fig 1 |
- Validation data
Figure 1. Western blot analysis using the Diagenode antibody directed against STAT2Y690p
Lysates from Jurkat cells treated with IFN-a (lane 2) or untreated control cells (lane 1) were analysed by Western blot using the Diagenode antibody against STAT2Y690p (cat. No. C15410330) diluted 1:1,000. The position of the phosphorylated STAT2 is indicated on the right. The antibody recognizes the phopsphorylated STAT2 but does not react with the unphosphorylated protein. - 出版物
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