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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

Minimization of gene editing off-target effects by tissue restricti...
Published: January, 2025
Abstract: Therapeutic in vivo gene editing with highly specific nucleases has the potential to revolutionize treatment for a wide range of human di... Read more »
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Tagmentase
The senolytic cocktail, dasatinib and quercetin, impacts the chroma...
Published: January, 2025
Abstract: One promising strategy to alleviate aging symptoms is the treatment with senolytics that is compounds which selectively eliminate senescent cells. ... Read more »
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Antibody
Elevating RNA m5C methylation provides a promising strategy for cro...
Published: January, 2025
Abstract: RNA 5-methylcytidine (m5C) has been identified as a key epi-transcriptomic modification of mRNAs involved in regulating multiple post-transcription... Read more »
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DNA Methylation
Schistosoma mansoni antigen induced innate immune memory features m...
Published: January, 2025
Abstract: We have previously identified that S. mansoni infection induces a unique form of myeloid training that protects male but not female mice ... Read more »
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ATAC-seq
Accelerated epigenetic ageing after burn injury
Published: January, 2025
Abstract: Individuals who suffer a major burn injury are at higher risk of developing a range of age-associated diseases prematurely leading to an increase i... Read more »
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Infinium Human MethylationEPIC Array Service
m3C is a mitochondrial mRNA modification which promotes tumor progr...
Published: January, 2025
Abstract: Mitochondrial mRNA modifications are suggested to play a role in fine-tuning mitochondrial gene expression and function. However, the epitranscript... Read more »
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Antibody
Concurrent RB1 and P53 pathway disruption predisposes to the develo...
Published: January, 2025
Abstract: The foremost feature of glioblastoma (GBM), the most frequent malignant brain tumours in adults, is a remarkable degree of intra- and inter-tumour ... Read more »
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Infinium Human MethylationEPIC Array Service
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin conden...
Published: January, 2025
Abstract: Abstract The compaction of chromatin is a prevalent paradigm in gene repression. Chromatin compaction is commonly thought to repress transcripti... Read more »
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ATAC-seq
Maternal obesity alters histone modifications mediated by the inter...
Published: January, 2025
Abstract: Neurodevelopmental disorders have complex origins that manifest early during embryonic growth and are associated with intricate gene regulation dyn... Read more »
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Bioruptor
MARTRE family proteins negatively regulate CCR4-NOT activity to pro...
Published: January, 2025
Abstract: The mammalian early embryo development requires translation of maternal mRNA inherited from the oocyte. While poly(A) tail length influences mRNA t... Read more »
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D-Plex small RNA-seq
A20’s Linear Ubiquitin Binding Motif Restrains Pathogenic Activatio...
Published: January, 2025
Abstract: A20, encoded by the TNFAIP3 gene, is a protein linked to Crohn's disease and celiac disease in humans. We now find that mice expressing p... Read more »
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Tagmentase
MECOM is a master repressor of myeloid differentiation through dose...
Published: January, 2025
Abstract: Enhancer translocations, due to 3q26 rearrangements, drive out-of-context MECOM expression in an aggressive subtype of acute myeloid leukemia (AML)... Read more »
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Antibody Microplex Library Preparation kit
Dysregulation of Myelination in Focal Cortical Dysplasia Type II of...
Published: December, 2024
Abstract: Focal cortical dysplasias (FCDs) are local malformations of the human neocortex and a leading cause of intractable epilepsy. FCDs are classified in... Read more »
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IPure kit iDeal ChIP-seq Kit for Transcription Factors
Mission SpaceX CRS-19 RRRM-1 space flight induced skin genomic plas...
Published: December, 2024
Abstract: Highlights Exposure to space environment causes genome-wide adaptive epigenetic changes Space-exposure adaptive genome-wide changes a... Read more »
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Premium RRBS Kit DNA Methylation Profiling (RRBS Service)
Assessing the impact of whole genome duplication on gene expression...
Published: December, 2024
Abstract: Whole genome duplication (WGD) generates new genetic material that can contribute to the evolution of the regulation of developmental processes and... Read more »
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ATAC-seq
Histone variant H3.5 in testicular cell differentiation and its int...
Published: December, 2024
Abstract: Testicular cell differentiation is a highly regulated process, essential for male reproductive health. The histone variant H3.5 is apparently a cri... Read more »
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MagMeDIP kit
TurboCas: A method for locus-specific labeling of genomic regions a...
Published: December, 2024
Abstract: Regulation of gene expression during development and stress response requires the concerted action of transcription factors and chromatin-binding p... Read more »
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CRISPR
The oncogenic lncRNA MIR503HG suppresses cellular senescence counte...
Published: December, 2024
Abstract: Background The androgen receptor (AR), a ligand-dependent transcription factor, plays a key role in regulating prostate cancer (PCa) growth. The n... Read more »
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iDeal ChIP-seq Kit for Transcription Factors
RNA Pol-II transcripts in nucleolar associated domains of cancer ce...
Published: December, 2024
Abstract: We performed a comparative study of the non-ribosomal gene content of nucleoli from seven cancer cell lines, using identical methods of purificatio... Read more »
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Microplex Library Preparation kit iDeal ChIP-seq Kit for Histones
Single chromatin fiber profiling and nucleosome position mapping in...
Published: December, 2024
Abstract: Motivation Nucleosomes are the basic unit of chromatin, but genome-scale maps of nucleosome positioning along chromatin fibers do not exist for ... Read more »
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Megaruptor
Independent evaluation of an 11-CpG panel for age estimation in blood
Published: December, 2024
Abstract: Highlights A set of 11 CpGs for age prediction was investigated in 148 Danish blood samples. Assay optimization improved covera... Read more »
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Premium Bisulfite Kit
Exploring the Epigenetic Landscape of Spermatozoa: Impact of Oxidat...
Published: December, 2024
Abstract: Reproductive success is dependent on gamete integrity, and oxidative stress alters male nuclei, meaning that no DNA repair is possible due to chrom... Read more »
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Antibody
PDGFRA is a conserved HAND2 effector during early cardiac development
Published: December, 2024
Abstract: The basic helix–loop–helix transcription factor HAND2 has multiple roles during vertebrate organogenesis, including cardiogenesis. Howe... Read more »
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True MicroChIP kit
EOMES establishes mesoderm and endoderm differentiation potential t...
Published: December, 2024
Abstract: Highlights Enhancer chromatin is dynamically remodeled during mesoderm/endoderm (ME) differentiation Global ME enhancer accessi... Read more »
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Antibody iDeal ChIP-seq Kit for Transcription Factors
Spatial organizations of heterochromatin underpin nuclear structura...
Published: December, 2024
Abstract: Highlights Cardiomyocytes acquire characteristic spatial organizations of heterochromatin (SOH) High levels of H2B-mCherry disr... Read more »
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ATAC-seq
Interferon-gamma rescues FK506 dampened dendritic cell calcineurin-...
Published: December, 2024
Abstract: IScience Highlights Calcineurin inhibitors block DC maturation in response to A. fumigatus Lack of DC maturation impairs T... Read more »
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Antibody IPure kit Microplex Library Preparation kit iDeal ChIP-seq Kit for Histones
ETV2/ER71 regulates hematovascular lineage generation and vasculari...
Published: December, 2024
Abstract: Highlights Interaction of ETV2 and KDM4A decreases H3K9 trimethylation on hematovascular genes. ETV2 and KDM4A cooperatively re... Read more »
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Microplex Library Preparation kit iDeal ChIP-seq Kit for Histones Chromatin Profiling (ChIP-seq) Services
Epi-microRNA mediated metabolic reprogramming counteracts hypoxia t...
Published: December, 2024
Abstract: To increase antibody affinity against pathogens, positively selected GC-B cells initiate cell division in the light zone (LZ) of germinal centers (... Read more »
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Microplex Library Preparation kit
Gene mobility elements mediate cell type specific genome organizati...
Published: December, 2024
Abstract: Understanding the level of genome organization that governs gene regulation remains a challenge despite advancements in chromatin profiling techniq... Read more »
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Tagmentase
NUP98 fusion proteins and KMT2A-MENIN antagonize PRC1.1 to drive ge...
Published: November, 2024
Abstract: Highlights Degradation of NUP98-fp halts nascent transcription of key oncogenes within 1 h NUP98-fp loss results in accumulat... Read more »
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Antibody

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